The Utilization of Reversible Acetylcholinesterase Inhibitors Case Study

The Utilization of Reversible Acetylcholinesterase Inhibitors - Case Study ExampleApparently, there is the need for more selective information to confirm current preliminary findings, as well as for more data on head-to-head comparisons of the two-sided acetylcholinesterase inhibitors.The purpose of this paper is to review the obtainable literature on the utilization of reversible acetylcholinesterase inhibitors in the management of Alzheimers dementia. The review will address issues of current interest surrounding the mechanism of treat of the reversible acetylcholinesterase inhibitors, the difficulties associated with designing appropriate clinical trial methodologies, issues concerning the relevance of current trial methodologies to long-term care settings, the current state of knowledge with regard to a putative neuroprotective effect of the reversible acetylcholinesterase inhibitors, new technological methods for assessing efficacy of reversible acetylcholinesterase inhibitors , and issues with available information on parallel comparisons between the commonly used reversible acetylcholinesterase inhibitors. Finally, practical issues surrounding the clinical use of the reversible acetylcholinesterase inhibitors will be reviewed, with a focus on associated adverse drug reactions and optimization of dosage regimens.In the United States, there are estimated to be possibly up to 4.8 million cases (Brookmeyer, Gray, & Kawas, 1998). It is predominant among the people over 65 (Hebert et al., 1995) with a prevalence of about 6% to 8%, and more than 50% of people aged 85 years and older experience bouts of dementia (Jay M. Ellis, 2005 Samanta et al., 2006) . Given the current population demographic trends in the United States and the prevalence of Alzheimers disease, the National Institutes of Health has projected that, by the year 2030, there could be 8.5 million Alzheimers patients in America (J. M. Ellis & Ellis, 2005) .Alzheimers dementia incapacitates the suf ferers from performing normal activities of daily living (ADL), and as the disease worsens, they become unable to function without assistance and have to rely on early(a) people for their everyday care, whether family caregivers or nursing home care providers (Bullock & Bullock, 2004 Jay M. Ellis, 2005).